Muscle spindle and golgi tendon organ6/25/2023 ![]() So that's going to activate the muscle spindle afferent and it's not going to activate much at all, the Golgi tendon afferent. And so far, this is a passive stretch of a muscle. Because again, the Golgi tendon organ is not so much sensitive to a change in muscle length, it's sensitive to the active contraction of the muscle. ![]() So here the muscle is lengthening, and so there's going to be an increase in activity in our muscle spindle afferents as this muscle is stretched, okay? Now, while that stretch is happening, there's really not much change and the afferent activity derive from the Golgi tendon organ. And let's begin by considering what happens when a muscle is stretched against some kind of load that's being applied. So, let's look at how muscle spindles and Golgi tendon organs might operate in a coordinated fashion during muscle activity. The course concludes with a survey of the association systems of the cerebral hemispheres, with an emphasis on cortical networks that integrate perception, memory and emotion in organizing behavior and planning for the future we will also consider brain systems for maintaining homeostasis and regulating brain state. Next, we turn our attention to the neurobiological mechanisms for building the nervous system in embryonic development and in early postnatal life we will also consider how the brain changes across the lifespan. In this unit, we will examine the organization and function of the brain and spinal mechanisms that govern bodily movement. Here, you will learn the overall organization and function of the sensory systems that contribute to our sense of self relative to the world around us: somatic sensory systems, proprioception, vision, audition, and balance senses. This unit addresses the fundamental mechanisms of neuronal excitability, signal generation and propagation, synaptic transmission, post synaptic mechanisms of signal integration, and neural plasticity. ![]() This unit covers the surface anatomy of the human brain, its internal structure, and the overall organization of sensory and motor systems in the brainstem and spinal cord. This course comprises six units of content organized into 12 weeks, with an additional week for a comprehensive final exam: Nevertheless, our aim is to faithfully present in scope and rigor a medical school caliber course experience. However, there are some topics (e.g., biological psychiatry) and several learning experiences (e.g., hands-on brain dissection) that we provide in the corresponding course offered in the Duke University School of Medicine on campus that we are not attempting to reproduce in Medical Neuroscience online. This online course is designed to include all of the core concepts in neurophysiology and clinical neuroanatomy that would be presented in most first-year neuroscience courses in schools of medicine. The course will build upon knowledge acquired through prior studies of cell and molecular biology, general physiology and human anatomy, as we focus primarily on the central nervous system. The overall goal of this course is to provide the foundation for understanding the impairments of sensation, action and cognition that accompany injury, disease or dysfunction in the central nervous system. In this course, you will discover the organization of the neural systems in the brain and spinal cord that mediate sensation, motivate bodily action, and integrate sensorimotor signals with memory, emotion and related faculties of cognition. ![]() Medical Neuroscience explores the functional organization and neurophysiology of the human central nervous system, while providing a neurobiological framework for understanding human behavior.
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